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Drugs And Genes
Negative Drug Target Genes
GENE_SYMBOL DRUG_NAME Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) Potency (nM) AC50 (nM) Datasource
PIK3R2 2,4-diamino-6-[[(1S)-1-(5-chloro-4-oxo-3-piperidin-3-ylquinazolin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile NA 5600000 NA NA NA NA BindingDB
PIK3R2 5-chloro-2-[(2S)-1-imidazo[2,1-f][1,2,4]triazin-4-ylpyrrolidin-2-yl]-3-piperazin-1-ylquinazolin-4-one NA 900000 NA NA NA NA BindingDB
PIK3R2 4-amino-6-[[(1S)-1-(5-chloro-4-oxo-3-pyrrolidin-3-ylquinazolin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile NA 160000 NA NA NA NA BindingDB
PIK3R2 2-[(1S)-1-[[6-amino-5-[2-(5-fluoropyridin-2-yl)ethynyl]pyrimidin-4-yl]amino]ethyl]-3-(azetidin-3-yl)-5-chloroquinazolin-4-one NA 1000000 NA NA NA NA BindingDB
PIK3R2 2,4-diamino-6-[[(1S)-1-[5-chloro-4-oxo-3-(4-propan-2-ylpiperazin-1-yl)quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile NA 120000 NA NA NA NA BindingDB
PIK3R2 2-amino-4-chloro-6-[[(1S)-1-[5-chloro-4-oxo-3-[4-(2,2,2-trifluoroethyl)piperazin-1-yl]quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile NA 1400000 NA NA NA NA BindingDB
PIK3R2 4-amino-6-[[(1S)-1-(5-chloro-4-oxo-3-piperidin-3-ylquinazolin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile NA 270000 NA NA NA NA BindingDB
PIK3R2 2,4-diamino-6-[[(S)-(5-chloro-3-morpholin-4-yl-4-oxoquinazolin-2-yl)-cyclopropylmethyl]amino]pyrimidine-5-carbonitrile NA 134000 NA NA NA NA BindingDB
PIK3R2 2,4-diamino-6-[[(1S)-1-[5-chloro-4-oxo-3-[(3S)-oxolan-3-yl]quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile NA 192000 NA NA NA NA BindingDB
PIK3R2 5-chloro-3-(1-ethylpyrrolidin-3-yl)-2-[(1S)-1-(7H-purin-6-ylamino)ethyl]quinazolin-4-one NA 4700000 NA NA NA NA BindingDB
PIK3R2 2-[(S)-cyclopropyl-(imidazo[2,1-f][1,2,4]triazin-4-ylamino)methyl]-5,8-difluoro-3-piperazin-1-ylquinazolin-4-one NA 210000 NA NA NA NA BindingDB
PIK3R2 4-amino-6-[[(1S)-1-[5-chloro-4-oxo-3-[3-(trifluoromethyl)piperazin-1-yl]quinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile NA 820000 NA NA NA NA BindingDB
PIK3R2 2-amino-4-chloro-6-[[(1S)-1-[5-chloro-3-[4-(2,2-difluoroethyl)piperazin-1-yl]-4-oxoquinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile NA 600000 NA NA NA NA BindingDB
PIK3R2 3-(azepan-4-yl)-5-chloro-2-[(1S)-1-(pyrido[3,2-d]pyrimidin-4-ylamino)ethyl]quinazolin-4-one NA 520000 NA NA NA NA BindingDB
PIK3R2 2,4-diamino-6-[[(1S)-1-[5-chloro-3-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]-4-oxoquinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile NA 290000 NA NA NA NA BindingDB
PIK3R2 2-amino-4-[[(1S)-1-[5-chloro-4-oxo-3-[4-[[4-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]quinazolin-2-yl]propyl]amino]-6-methylpyrimidine-5-carbonitrile NA 4500000 NA NA NA NA BindingDB
PIK3R2 3-[(4S)-azepan-4-yl]-5-chloro-2-[(1S)-1-[(2,6-diamino-5-chloropyrimidin-4-yl)amino]ethyl]quinazolin-4-one NA 660000 NA NA NA NA BindingDB
PIK3R2 5-chloro-3-[4-(2,2-difluoroethyl)piperazin-1-yl]-2-[(1S)-1-([1,3]thiazolo[5,4-d]pyrimidin-7-ylamino)ethyl]quinazolin-4-one NA 1800000 NA NA NA NA BindingDB
PIK3R2 2-amino-4-[[(1S)-1-[5-chloro-3-[4-(2,2-difluoroethyl)piperazin-1-yl]-4-oxoquinazolin-2-yl]ethyl]amino]-6-methylpyrimidine-5-carbonitrile NA 300000 NA NA NA NA BindingDB
PIK3R2 4-amino-6-[[(1S)-1-[5-chloro-3-(1-methylpiperidin-4-yl)-4-oxoquinazolin-2-yl]ethyl]amino]pyrimidine-5-carbonitrile NA 460000 NA NA NA NA BindingDB