Official Symbol

CDKN2B-AS1  provided by HGNC

Official Full Name

CDKN2B antisense RNA 1 

Gene ID

100048912 

Chromosome

chr9

Start Site

21994139

End Site

22128103

Strand

+ 

Assembly

GRCh38

Biotype

lncRNA

Also known as

ANRIL|CDKN2B-AS|CDKN2BAS|NCRNA00089|PCAT12|p15AS 

Summary

This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014] 

Official Symbol

IGF2BP3  provided by HGNC

Official Full Name

insulin like growth factor 2 mRNA binding protein 3 

m6A Category

readers 

Gene ID

10643 

Chromosome

chr7 

Start Site

23310209 

End Site

23470491 

Strand

- 

Assembly

GRCh38

Biotype

protein coding 

Also known as

CT98|IMP-3|IMP3|KOC|KOC1|VICKZ3 

Summary

"The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]"