Official Symbol

NBR2  provided by HGNC

Official Full Name

neighbor of BRCA1 lncRNA 2 

Gene ID

10230 

Chromosome

chr17

Start Site

43125551

End Site

43153671

Strand

+ 

Assembly

GRCh38

Biotype

lncRNA

Also known as

NCRNA00192 

Summary

This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 nucleotides upstream of the last splice site for the transcript, suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. Glucose starvation induces the expression of this gene and the long non-coding RNA transcribed by it functions with AMP-activated protein kinase in mediating the energy stress response. [provided by RefSeq, Aug 2016] 

Official Symbol

WTAP  provided by HGNC

Official Full Name

WT1 associated protein 

m6A Category

writers 

Gene ID

9589 

Chromosome

chr6 

Start Site

159725585 

End Site

159756319 

Strand

+ 

Assembly

GRCh38

Biotype

protein coding 

Also known as

Mum2 

Summary

"The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012]"