Official Symbol

PCA3  provided by HGNC

Official Full Name

prostate cancer associated 3 

Gene ID

50652 

Chromosome

chr9

Start Site

76691980

End Site

76863307

Strand

+ 

Assembly

GRCh38

Biotype

lncRNA

Also known as

DD3|NCRNA00019|PCAT3|PRUNE2-AS1 

Summary

This gene produces a spliced, long non-coding RNA that is highly overexpressed in most types of prostate cancer cells and is used as a specific biomarker for this type of cancer. This gene is embedded in an intronic region of the prune2 gene on the opposite DNA strand. The transcript regulates prune2 levels through formation of a double-stranded RNA that undergoes adenosine deaminase acting on RNA-dependent adenosine-to-inosine RNA editing. In prostate cancer derived cells, overexpression of PCA induced downregulation of prune2, leading to decreased cell proliferation. Conversely, silencing in prostate cancer cells resulted in increased proliferation. Regulation of this gene appears to be sensitive to androgen-receptor activation, a molecular signature of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017] 

Official Symbol

YTHDC2  provided by HGNC

Official Full Name

YTH domain containing 2 

m6A Category

readers 

Gene ID

64848 

Chromosome

chr5 

Start Site

113513694 

End Site

113595285 

Strand

+ 

Assembly

GRCh38

Biotype

protein coding 

Also known as

CAHL|hYTHDC2 

Summary

"This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line. [provided by RefSeq, Sep 2016]"