Official Symbol
HOTAIR provided by HGNC
Official Full Name
HOX transcript antisense RNA
Gene ID
100124700
Chromosome
chr12
Start Site
53962308
End Site
53974956
Strand
-
Assembly
GRCh38
Biotype
lncRNA
Also known as
HOXAS|HOXC-AS4|HOXC11-AS1|NCRNA00072
Summary
This gene is located within the Homeobox C (HOXC) gene cluster on chromosome 12 and is co-expressed with the HOXC genes. It functions through an RNA product, which binds lysine specific demethylase 1 (LSD1) and Polycomb repressive complex 2 (PRC2), and serves as a scaffold to assemble these regulators at the HOXD gene cluster, thereby promoting epigenetic repression of HOXD. This gene is highly expressed in multiple tumors. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Feb 2019]