M6ARegulator:ENSG00000198492
Official Symbol
YTHDF2 provided by HGNC
Official Full Name
YTH N6-methyladenosine RNA binding protein 2
m6A Category
readers
Gene ID
51441
Chromosome
chr1
Start Site
28736621
End Site
28769775
Strand
+
Assembly
GRCh38
Biotype
protein coding
Also known as
CAHL|DF2|HGRG8|NY-REN-2
Summary
"This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]"