Official Symbol

GAS5  provided by HGNC

Official Full Name

growth arrest specific 5 

Gene ID

60674 

Chromosome

chr1

Start Site

173858559

End Site

173868882

Strand

- 

Assembly

GRCh38

Biotype

lncRNA

Also known as

NCRNA00030|SNHG2 

Summary

This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015] 

Official Symbol

HNRNPC  provided by HGNC

Official Full Name

heterogeneous nuclear ribonucleoprotein C 

m6A Category

readers 

Gene ID

3183 

Chromosome

chr14 

Start Site

21209136 

End Site

21269494 

Strand

- 

Assembly

GRCh38

Biotype

protein coding 

Also known as

C1|C2|HNRNP|HNRPC|SNRPC 

Summary

"This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]"