Official Symbol

GAS5  provided by HGNC

Official Full Name

growth arrest specific 5 

Gene ID

60674 

Chromosome

chr1

Start Site

173858559

End Site

173868882

Strand

- 

Assembly

GRCh38

Biotype

lncRNA

Also known as

NCRNA00030|SNHG2 

Summary

This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015] 

Official Symbol

IGF2BP3  provided by HGNC

Official Full Name

insulin like growth factor 2 mRNA binding protein 3 

m6A Category

readers 

Gene ID

10643 

Chromosome

chr7 

Start Site

23310209 

End Site

23470491 

Strand

- 

Assembly

GRCh38

Biotype

protein coding 

Also known as

CT98|IMP-3|IMP3|KOC|KOC1|VICKZ3 

Summary

"The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]"