Official Symbol
MALAT1 provided by HGNC
Official Full Name
metastasis associated lung adenocarcinoma transcript 1
Gene ID
378938
Chromosome
chr11
Start Site
65497688
End Site
65506516
Strand
+
Assembly
GRCh38
Biotype
lncRNA
Also known as
HCN|LINC00047|NCRNA00047|NEAT2|PRO2853
Summary
This gene produces a precursor transcript from which a long non-coding RNA is derived by RNase P cleavage of a tRNA-like small ncRNA (known as mascRNA) from its 3' end. The resultant mature transcript lacks a canonical poly(A) tail but is instead stabilized by a 3' triple helical structure. This transcript is retained in the nucleus where it is thought to form molecular scaffolds for ribonucleoprotein complexes. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer metastasis and cell migration, and it is involved in cell cycle regulation. Its upregulation in multiple cancerous tissues has been associated with the proliferation and metastasis of tumor cells. [provided by RefSeq, Mar 2015]