M6ARegulator:ENSG00000047188
Official Symbol
YTHDC2 provided by HGNC
Official Full Name
YTH domain containing 2
m6A Category
readers
Gene ID
64848
Chromosome
chr5
Start Site
113513694
End Site
113595285
Strand
+
Assembly
GRCh38
Biotype
protein coding
Also known as
CAHL|hYTHDC2
Summary
"This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line. [provided by RefSeq, Sep 2016]"