Official Symbol
PVT1 provided by HGNC
Official Full Name
Pvt1 oncogene
Gene ID
5820
Chromosome
chr8
Start Site
127794526
End Site
128187101
Strand
+
Assembly
GRCh38
Biotype
lncRNA
Also known as
LINC00079|MIR1204HG|NCRNA00079|onco-lncRNA-100
Summary
This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. [provided by RefSeq, Sep 2015]