Official Symbol

PVT1  provided by HGNC

Official Full Name

Pvt1 oncogene 

Gene ID

5820 

Chromosome

chr8

Start Site

127794526

End Site

128187101

Strand

+ 

Assembly

GRCh38

Biotype

lncRNA

Also known as

LINC00079|MIR1204HG|NCRNA00079|onco-lncRNA-100 

Summary

This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. [provided by RefSeq, Sep 2015] 

Official Symbol

FTO  provided by HGNC

Official Full Name

FTO alpha-ketoglutarate dependent dioxygenase 

m6A Category

erasers 

Gene ID

79068 

Chromosome

chr16 

Start Site

53701692 

End Site

54158512 

Strand

+ 

Assembly

GRCh38

Biotype

protein coding 

Also known as

ALKBH9|BMIQ14|GDFD 

Summary

"This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]"