Official Symbol

NBR2  provided by HGNC

Official Full Name

neighbor of BRCA1 lncRNA 2 

Gene ID

10230 

Chromosome

chr17

Start Site

43125551

End Site

43153671

Strand

+ 

Assembly

GRCh38

Biotype

lncRNA

Also known as

NCRNA00192 

Summary

This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 nucleotides upstream of the last splice site for the transcript, suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. Glucose starvation induces the expression of this gene and the long non-coding RNA transcribed by it functions with AMP-activated protein kinase in mediating the energy stress response. [provided by RefSeq, Aug 2016] 

Official Symbol

HNRNPC  provided by HGNC

Official Full Name

heterogeneous nuclear ribonucleoprotein C 

m6A Category

readers 

Gene ID

3183 

Chromosome

chr14 

Start Site

21209136 

End Site

21269494 

Strand

- 

Assembly

GRCh38

Biotype

protein coding 

Also known as

C1|C2|HNRNP|HNRPC|SNRPC 

Summary

"This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]"