Official Symbol

XIST  provided by HGNC

Official Full Name

X inactive specific transcript 

Gene ID

7503 

Chromosome

chrX

Start Site

73820649

End Site

73852723

Strand

- 

Assembly

GRCh38

Biotype

lncRNA

Also known as

DXS1089|DXS399E|LINC00001|NCRNA00001|SXI1|swd66 

Summary

X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females. The process is regulated by several factors, including a region of chromosome X called the X inactivation center (XIC). The XIC comprises several non-coding and protein-coding genes, and this gene was the first non-coding gene identified within the XIC. This gene is expressed exclusively from the XIC of the inactive X chromosome, and is essential for the initiation and spread of X-inactivation. The transcript is a spliced RNA. Alternatively spliced transcript variants have been identified, but their full length sequences have not been determined. Mutations in the XIST promoter cause familial skewed X inactivation. [provided by RefSeq, Apr 2012] 

Official Symbol

METTL3  provided by HGNC

Official Full Name

"methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit" 

m6A Category

writers 

Gene ID

56339 

Chromosome

chr14 

Start Site

21498133 

End Site

21511342 

Strand

- 

Assembly

GRCh38

Biotype

protein coding 

Also known as

IME4|M6A|MT-A70|Spo8|hMETTL3 

Summary

"This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]"