Official Symbol

PVT1  provided by HGNC

Official Full Name

Pvt1 oncogene 

Gene ID

5820 

Chromosome

chr8

Start Site

127794526

End Site

128187101

Strand

+ 

Assembly

GRCh38

Biotype

lncRNA

Also known as

LINC00079|MIR1204HG|NCRNA00079|onco-lncRNA-100 

Summary

This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. [provided by RefSeq, Sep 2015] 

Official Symbol

IGF2BP1  provided by HGNC

Official Full Name

insulin like growth factor 2 mRNA binding protein 1 

m6A Category

readers 

Gene ID

10642 

Chromosome

chr17 

Start Site

48997385 

End Site

49056145 

Strand

+ 

Assembly

GRCh38

Biotype

protein coding 

Also known as

CRD-BP|CRDBP|IMP-1|IMP1|VICKZ1|ZBP1 

Summary

"This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]"