Official Symbol

PVT1  provided by HGNC

Official Full Name

Pvt1 oncogene 

Gene ID

5820 

Chromosome

chr8

Start Site

127794526

End Site

128187101

Strand

+ 

Assembly

GRCh38

Biotype

lncRNA

Also known as

LINC00079|MIR1204HG|NCRNA00079|onco-lncRNA-100 

Summary

This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. [provided by RefSeq, Sep 2015] 

Official Symbol

IGF2BP2  provided by HGNC

Official Full Name

insulin like growth factor 2 mRNA binding protein 2 

m6A Category

readers 

Gene ID

10644 

Chromosome

chr3 

Start Site

185643130 

End Site

185825042 

Strand

- 

Assembly

GRCh38

Biotype

protein coding 

Also known as

IMP-2|IMP2|VICKZ2 

Summary

"This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]"