Official Symbol

CDKN2B-AS1  provided by HGNC

Official Full Name

CDKN2B antisense RNA 1 

Gene ID

100048912 

Chromosome

chr9

Start Site

21994139

End Site

22128103

Strand

+ 

Assembly

GRCh38

Biotype

lncRNA

Also known as

ANRIL|CDKN2B-AS|CDKN2BAS|NCRNA00089|PCAT12|p15AS 

Summary

This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014] 

Official Symbol

RBM15B  provided by HGNC

Official Full Name

RNA binding motif protein 15B 

m6A Category

writers 

Gene ID

29890 

Chromosome

chr3 

Start Site

51391285 

End Site

51397908 

Strand

+ 

Assembly

GRCh38

Biotype

protein coding 

Also known as

HUMAGCGB|HsOTT3|OTT3 

Summary

"Members of the SPEN (Split-end) family of proteins, including RBM15B, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]"