Official Symbol

DLEU2  provided by HGNC

Official Full Name

deleted in lymphocytic leukemia 2 

Gene ID

8847 

Chromosome

chr13

Start Site

49956670

End Site

50125720

Strand

- 

Assembly

GRCh38

Biotype

lncRNA

Also known as

ALT1|BCMSUN|DLB2|LEU2|LINC00022|MIR15AHG|NCRNA00022|RFP2|RFP2OS|TRIM13OS 

Summary

This locus represents a microRNA host gene and also produces long alternatively spliced non-coding RNAs. This genome region was observed to be deleted or epigenetically suppressed in leukemia, and was implicated as a negative regulator of cell proliferation. However, an alternative transcript produced at this locus was also found to promote progression through the cell cycle via angiotensin I converting enzyme 2 and cyclin D1. [provided by RefSeq, Dec 2017] 

Official Symbol

YTHDC2  provided by HGNC

Official Full Name

YTH domain containing 2 

m6A Category

readers 

Gene ID

64848 

Chromosome

chr5 

Start Site

113513694 

End Site

113595285 

Strand

+ 

Assembly

GRCh38

Biotype

protein coding 

Also known as

CAHL|hYTHDC2 

Summary

"This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line. [provided by RefSeq, Sep 2016]"