Official Symbol
FENDRR provided by HGNC
Official Full Name
FOXF1 adjacent non-coding developmental regulatory RNA
Gene ID
400550
Chromosome
chr16
Start Site
86474529
End Site
86509099
Strand
-
Assembly
GRCh38
Biotype
lncRNA
Also known as
FOXF1-AS1|FOXF1AS1|TCONS_00024240|lincFOXF1|onco-lncRNA-21
Summary
This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It has been suggested that this transcript may play a role in the progression of gastric cancer. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]