Official Symbol

MALAT1  provided by HGNC

Official Full Name

metastasis associated lung adenocarcinoma transcript 1 

Gene ID

378938 

Chromosome

chr11

Start Site

65497688

End Site

65506516

Strand

+ 

Assembly

GRCh38

Biotype

lncRNA

Also known as

HCN|LINC00047|NCRNA00047|NEAT2|PRO2853 

Summary

This gene produces a precursor transcript from which a long non-coding RNA is derived by RNase P cleavage of a tRNA-like small ncRNA (known as mascRNA) from its 3' end. The resultant mature transcript lacks a canonical poly(A) tail but is instead stabilized by a 3' triple helical structure. This transcript is retained in the nucleus where it is thought to form molecular scaffolds for ribonucleoprotein complexes. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer metastasis and cell migration, and it is involved in cell cycle regulation. Its upregulation in multiple cancerous tissues has been associated with the proliferation and metastasis of tumor cells. [provided by RefSeq, Mar 2015] 

Official Symbol

HNRNPA2B1  provided by HGNC

Official Full Name

heterogeneous nuclear ribonucleoprotein A2/B1 

m6A Category

readers 

Gene ID

3181 

Chromosome

chr7 

Start Site

26173057 

End Site

26201529 

Strand

- 

Assembly

GRCh38

Biotype

protein coding 

Also known as

HNRNPA2|HNRNPB1|HNRPA2|HNRPA2B1|HNRPB1|IBMPFD2|RNPA2|SNRPB1 

Summary

"This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]"