Official Symbol

XIST  provided by HGNC

Official Full Name

X inactive specific transcript 

Gene ID

7503 

Chromosome

chrX

Start Site

73820649

End Site

73852723

Strand

- 

Assembly

GRCh38

Biotype

lncRNA

Also known as

DXS1089|DXS399E|LINC00001|NCRNA00001|SXI1|swd66 

Summary

X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females. The process is regulated by several factors, including a region of chromosome X called the X inactivation center (XIC). The XIC comprises several non-coding and protein-coding genes, and this gene was the first non-coding gene identified within the XIC. This gene is expressed exclusively from the XIC of the inactive X chromosome, and is essential for the initiation and spread of X-inactivation. The transcript is a spliced RNA. Alternatively spliced transcript variants have been identified, but their full length sequences have not been determined. Mutations in the XIST promoter cause familial skewed X inactivation. [provided by RefSeq, Apr 2012] 

Official Symbol

IGF2BP2  provided by HGNC

Official Full Name

insulin like growth factor 2 mRNA binding protein 2 

m6A Category

readers 

Gene ID

10644 

Chromosome

chr3 

Start Site

185643130 

End Site

185825042 

Strand

- 

Assembly

GRCh38

Biotype

protein coding 

Also known as

IMP-2|IMP2|VICKZ2 

Summary

"This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]"