Official Symbol

TSIX  provided by HGNC

Official Full Name

TSIX transcript, XIST antisense RNA 

Gene ID

9383 

Chromosome

chrX

Start Site

73792205

End Site

73829231

Strand

+ 

Assembly

GRCh38

Biotype

lncRNA

Also known as

LINC00013|NCRNA00013|XIST-AS|XIST-AS1|XISTAS 

Summary

In mammals, dosage compensation of genes on the X chromosome occurs by X inactivation, which is regulated in cis by the X-inactivation center (XIC) and expression of the XIST non-coding RNA. This gene expresses a non-coding antisense transcript across the 3' end of the XIST locus, and is coexpressed with XIST only from the inactive X chromosome. The mouse ortholog of this locus is required for imprinted X inactivation in extraembryonic tissues and silences Xist through modification of the chromatin structure in the Xist promoter region. In contrast, imprinted X inactivation does not occur in human extraembryonic tissues and transcripts from this locus do not repress XIST expression or affect random X chromosome inactivation in embryonic cells. This transcript is thought to be unspliced and extend over more than 30 kb, but its exact nature has not been determined. [provided by RefSeq, Jul 2008] 

Official Symbol

YTHDF2  provided by HGNC

Official Full Name

YTH N6-methyladenosine RNA binding protein 2 

m6A Category

readers 

Gene ID

51441 

Chromosome

chr1 

Start Site

28736621 

End Site

28769775 

Strand

+ 

Assembly

GRCh38

Biotype

protein coding 

Also known as

CAHL|DF2|HGRG8|NY-REN-2 

Summary

"This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]"