Official Symbol
TSIX provided by HGNC
Official Full Name
TSIX transcript, XIST antisense RNA
Gene ID
9383
Chromosome
chrX
Start Site
73792205
End Site
73829231
Strand
+
Assembly
GRCh38
Biotype
lncRNA
Also known as
LINC00013|NCRNA00013|XIST-AS|XIST-AS1|XISTAS
Summary
In mammals, dosage compensation of genes on the X chromosome occurs by X inactivation, which is regulated in cis by the X-inactivation center (XIC) and expression of the XIST non-coding RNA. This gene expresses a non-coding antisense transcript across the 3' end of the XIST locus, and is coexpressed with XIST only from the inactive X chromosome. The mouse ortholog of this locus is required for imprinted X inactivation in extraembryonic tissues and silences Xist through modification of the chromatin structure in the Xist promoter region. In contrast, imprinted X inactivation does not occur in human extraembryonic tissues and transcripts from this locus do not repress XIST expression or affect random X chromosome inactivation in embryonic cells. This transcript is thought to be unspliced and extend over more than 30 kb, but its exact nature has not been determined. [provided by RefSeq, Jul 2008]