Official Symbol

PWRN1  provided by HGNC

Official Full Name

Prader-Willi region non-protein coding RNA 1 

Gene ID

791114 

Chromosome

chr15

Start Site

24101827

End Site

24823365

Strand

+ 

Assembly

GRCh38

Biotype

lncRNA

Also known as

NCRNA00198 

Summary

This gene is located in the Prader-Willi syndrome (PWS) region of chromosome 15, which is known to undergo imprinting. The transcript is believed to be non-coding. It is bi-allelically expressed in testis and kidney, but mono-allelically expressed from the paternal allele in brain. This gene is poly-adenylated and is known to undergo alternative splicing. Transcript variants may represent part of a complex imprinting center-SNURF-SNRPN transcription unit. The contribution of this gene to the PWS phenotype is unknown, but it has been suggested that it may play a role in establishing paternal imprinting in the PWS region, perhaps by maintaining the paternal allele in an open chromatin configuration. [provided by RefSeq, Sep 2009] 

Official Symbol

HNRNPA2B1  provided by HGNC

Official Full Name

heterogeneous nuclear ribonucleoprotein A2/B1 

m6A Category

readers 

Gene ID

3181 

Chromosome

chr7 

Start Site

26173057 

End Site

26201529 

Strand

- 

Assembly

GRCh38

Biotype

protein coding 

Also known as

HNRNPA2|HNRNPB1|HNRPA2|HNRPA2B1|HNRPB1|IBMPFD2|RNPA2|SNRPB1 

Summary

"This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]"