Official Symbol

NBR2  provided by HGNC

Official Full Name

neighbor of BRCA1 lncRNA 2 

Gene ID

10230 

Chromosome

chr17

Start Site

43125551

End Site

43153671

Strand

+ 

Assembly

GRCh38

Biotype

lncRNA

Also known as

NCRNA00192 

Summary

This gene was identified by its close proximity on chromosome 17 to tumor suppressor gene BRCA1. Experimental evidence indicates that the two genes share a bi-directional promoter. Transcription for either gene is controlled individually by distinct transcriptional repressor factors. A short (112 amino acid) open reading frame is observed which includes a region derived from a LINE1 element. A strong Kozak signal is not observed for the putative ORF and the stop codon is more than 55 nucleotides upstream of the last splice site for the transcript, suggesting that the transcript is subject to nonsense-mediated decay. Therefore, this gene does not appear to encode a protein. Glucose starvation induces the expression of this gene and the long non-coding RNA transcribed by it functions with AMP-activated protein kinase in mediating the energy stress response. [provided by RefSeq, Aug 2016] 

Official Symbol

FTO  provided by HGNC

Official Full Name

FTO alpha-ketoglutarate dependent dioxygenase 

m6A Category

erasers 

Gene ID

79068 

Chromosome

chr16 

Start Site

53701692 

End Site

54158512 

Strand

+ 

Assembly

GRCh38

Biotype

protein coding 

Also known as

ALKBH9|BMIQ14|GDFD 

Summary

"This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]"