Official Symbol

MALAT1  provided by HGNC

Official Full Name

metastasis associated lung adenocarcinoma transcript 1 

Gene ID

378938 

Chromosome

chr11

Start Site

65497688

End Site

65506516

Strand

+ 

Assembly

GRCh38

Biotype

lncRNA

Also known as

HCN|LINC00047|NCRNA00047|NEAT2|PRO2853 

Summary

This gene produces a precursor transcript from which a long non-coding RNA is derived by RNase P cleavage of a tRNA-like small ncRNA (known as mascRNA) from its 3' end. The resultant mature transcript lacks a canonical poly(A) tail but is instead stabilized by a 3' triple helical structure. This transcript is retained in the nucleus where it is thought to form molecular scaffolds for ribonucleoprotein complexes. It may act as a transcriptional regulator for numerous genes, including some genes involved in cancer metastasis and cell migration, and it is involved in cell cycle regulation. Its upregulation in multiple cancerous tissues has been associated with the proliferation and metastasis of tumor cells. [provided by RefSeq, Mar 2015] 

Official Symbol

METTL3  provided by HGNC

Official Full Name

"methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit" 

m6A Category

writers 

Gene ID

56339 

Chromosome

chr14 

Start Site

21498133 

End Site

21511342 

Strand

- 

Assembly

GRCh38

Biotype

protein coding 

Also known as

IME4|M6A|MT-A70|Spo8|hMETTL3 

Summary

"This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]"