Official Symbol

LINC00461  provided by HGNC

Official Full Name

long intergenic non-protein coding RNA 461 

Gene ID

645323 

Chromosome

chr5

Start Site

88507546

End Site

88691057

Strand

- 

Assembly

GRCh38

Biotype

lncRNA

Also known as

ECONEXIN|EyeLinc1|NDIME|VISC 

Summary

This is an evolutionarily conserved gene that produces alternatively spliced long non-coding RNAs that may be expressed predominantly in the brain and visual cortex. These transcripts may be involved in tumorigenesis, as depletion by siRNA suppressed glioma cell division. Transcripts may also bind to and regulate the activity of miR-411-5p and argonaut 2, thereby altering the expression of genes involved in tumor growth. [provided by RefSeq, Nov 2017] 

Official Symbol

YTHDF2  provided by HGNC

Official Full Name

YTH N6-methyladenosine RNA binding protein 2 

m6A Category

readers 

Gene ID

51441 

Chromosome

chr1 

Start Site

28736621 

End Site

28769775 

Strand

+ 

Assembly

GRCh38

Biotype

protein coding 

Also known as

CAHL|DF2|HGRG8|NY-REN-2 

Summary

"This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]"