Official Symbol

GAS5  provided by HGNC

Official Full Name

growth arrest specific 5 

Gene ID

60674 

Chromosome

chr1

Start Site

173858559

End Site

173868882

Strand

- 

Assembly

GRCh38

Biotype

lncRNA

Also known as

NCRNA00030|SNHG2 

Summary

This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015] 

Official Symbol

IGF2BP1  provided by HGNC

Official Full Name

insulin like growth factor 2 mRNA binding protein 1 

m6A Category

readers 

Gene ID

10642 

Chromosome

chr17 

Start Site

48997385 

End Site

49056145 

Strand

+ 

Assembly

GRCh38

Biotype

protein coding 

Also known as

CRD-BP|CRDBP|IMP-1|IMP1|VICKZ1|ZBP1 

Summary

"This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]"