Official Symbol

CDKN2B-AS1  provided by HGNC

Official Full Name

CDKN2B antisense RNA 1 

Gene ID

100048912 

Chromosome

chr9

Start Site

21994139

End Site

22128103

Strand

+ 

Assembly

GRCh38

Biotype

lncRNA

Also known as

ANRIL|CDKN2B-AS|CDKN2BAS|NCRNA00089|PCAT12|p15AS 

Summary

This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014] 

Official Symbol

WTAP  provided by HGNC

Official Full Name

WT1 associated protein 

m6A Category

writers 

Gene ID

9589 

Chromosome

chr6 

Start Site

159725585 

End Site

159756319 

Strand

+ 

Assembly

GRCh38

Biotype

protein coding 

Also known as

Mum2 

Summary

"The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012]"