| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| CTSD |
N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)phenyl)-5-chloropicolinamide |
NA |
2370000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-(5-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-6-methoxypyridin-3-yl)-5-chloropicolinamide |
NA |
1420000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(4S,6S)-4-(5-((3-chloro-1,7-naphthyridin-8-yl)amino)-2,3-difluorophenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine |
NA |
104000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(4S,6S)-4-(2,3-difluoro-5-((2-methoxypyrido[3,4-b]pyrazin-5-yl)amino)phenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine |
NA |
519000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-5-chloro-4-fluorophenyl)-5-cyanopicolinamide |
NA |
487900 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(4S,6S)-4-(2,3-difluoro-5-((3-methoxypyridin-2-yl)amino)phenyl)-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine |
NA |
282000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-chloro-5-fluorophenyl)-5-chloropicolinamide |
NA |
407900 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(4aR,7aS)-2-amino-6-(5-fluoropyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl]-3,5-difluoropyridine-2-carboxamide |
NA |
169000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
3-amino-N-[6-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-5-fluoropyridin-2-yl]-5-(2,2,2-trifluoroethoxy)pyrazine-2-carboxamide |
NA |
106000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
Umibecestat |
NA |
205000 |
NA |
NA |
NA |
NA |
BindingDB|PubChem |
| CTSD |
(S)-3-chloro-1-fluoro-N7-(3-methylpyridin-2-yl)-5',6'-dihydrospiro[chromeno[2,3-c]pyridine-5,4'-[1,3]oxazine]-2',7-diamine |
NA |
386300 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[6-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-5-fluoropyridin-2-yl]-3,5-dichloropyridine-2-carboxamide |
NA |
217000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[6-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-5-fluoropyridin-2-yl]-3-chloro-5-(difluoromethoxy)pyridine-2-carboxamide |
NA |
236000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-but-2-ynoxypyridine-2-carboxamide |
NA |
783800 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(4S,6S)-4-[5-[2-[5-(difluoromethoxy)pyridin-2-yl]ethynyl]-2-fluorophenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine |
NA |
605000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]phenyl]-5-methoxypyridine-2-carboxamide |
NA |
3520000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(4S,6S)-4-(fluoromethyl)-4-[2-fluoro-5-(4-phenylpyridin-2-yl)oxyphenyl]-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine |
NA |
114000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide |
NA |
627600 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(4S,6S)-4-[2-fluoro-5-(6-fluoroquinazolin-2-yl)phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine |
NA |
758000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-prop-2-ynoxypyridine-2-carboxamide |
NA |
1189000|1330000 |
NA |
NA |
NA |
NA |
BindingDB |