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Drugs And Genes
Negative Drug Target Genes
GENE_SYMBOL DRUG_NAME Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) Potency (nM) AC50 (nM) Datasource
CTSD N-[3-[(4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-(1,3-oxazol-2-ylmethoxy)pyrazine-2-carboxamide NA 1045000 NA NA NA NA BindingDB
CTSD N-[3-[(4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluorophenyl]-5-prop-2-ynoxypyridine-2-carboxamide NA 666000 NA NA NA NA BindingDB
CTSD (4S,6S)-4-[2-fluoro-5-[2-(1H-indol-7-yl)ethynyl]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine NA 1130000 NA NA NA NA BindingDB
CTSD N-[3-[(4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-methoxypyridine-2-carboxamide NA 761600 NA NA NA NA BindingDB
CTSD N-[3-[(4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-methoxypyridine-2-carboxamide NA 1119000 NA NA NA NA BindingDB
CTSD (4S,6S)-4-[2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine NA 1080000 NA NA NA NA BindingDB
CTSD N-[3-[(4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4-fluoro-5-methylphenyl]-5-methoxy-3-methylpyridine-2-carboxamide NA 780500 NA NA NA NA BindingDB
CTSD (4S,6S)-4-[2-fluoro-5-(3-fluoropyridin-2-yl)oxyphenyl]-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-2-amine NA 2220000 NA NA NA NA BindingDB
CTSD N-[3-[(4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-bromo-3-fluoropyridine-2-carboxamide NA 928000 NA NA NA NA BindingDB
CTSD N-[3-[(1S,5R,6S)-3-amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-chloro-5-fluorophenyl]-5-methoxypyrazine-2-carboxamide NA 403830|646570 NA NA NA NA BindingDB
CTSD N-[3-[(1R,5S,6R)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-prop-2-ynoxypyrazine-2-carboxamide NA 1001000 NA NA NA NA BindingDB
CTSD (1R,5S,6R)-5-(difluoromethyl)-5-(2-fluoro-5-(5-(4-fluorophenyl)-4H-1,2,4-triazol-3-yl)phenyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine NA 249590 NA NA NA NA BindingDB
CTSD US9611261, Example 29 NA 462460 NA NA NA NA BindingDB
CTSD US9611261, Example 331 NA 1511900 NA NA NA NA BindingDB
CTSD N-[3-[(1R,5S,6R)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-bromopyrimidine-2-carboxamide NA 1015200 NA NA NA NA BindingDB
CTSD US9611261, Example 426 NA 195650 NA NA NA NA BindingDB
CTSD N-[3-[(1S,5R,6S)-3-amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-chloropyridine-2-carboxamide NA 339220|1021900 NA NA NA NA BindingDB
CTSD N-[3-[(1R,5S,6R)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-methoxypyrazine-2-carboxamide NA 4184000 NA NA NA NA BindingDB
CTSD N-[3-[(1R,5S,6R)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-methylphenyl]-5-cyanopyridine-2-carboxamide NA 715760 NA NA NA NA BindingDB
CTSD (7R)-7-[3-[(1R,5S,6R)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluoroanilino]-6,7-dihydro-5H-cyclopenta[b]pyridine-3-carbonitrile NA 131500|555020 NA NA NA NA BindingDB