| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| KLK7 |
[(3R,3aR,6R,6aR)-3-phenylmethoxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl] (2R)-3-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate |
NA |
239000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| KLK7 |
(Z)-2-cyano-3-(3-ethoxy-4-hydroxyphenyl)-N-(4-hydroxyphenyl)prop-2-enamide |
152000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| KLKB1 |
H-Cys(1)-Pro-Ala-Tyr-Ser-Arg-Tyr-Leu-Asp-Cys(1)-OH |
1000000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| KLKB1 |
(S)-1-(3,3-Diphenyl-propionyl)-pyrrolidine-2-carboxylic acid (4-amino-cyclohexylmethyl)-amide; TFA |
1000000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| KLKB1 |
(S)-1-(2-Amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid 2,5-dichloro-benzylamide |
586000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| KLKB1 |
(S)-1-(2-5H-Dibenzo[a,d]cyclohepten-5-yl-acetyl)-pyrrolidine-2-carboxylic acid (4-amino-cyclohexylmethyl)-amide; hydrochloride |
775000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| KLKB1 |
(S)-1-(3,3-Dicyclohexyl-propionyl)-pyrrolidine-2-carboxylic acid (4-amino-cyclohexylmethyl)-amide; hydrochloride |
170000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| KLKB1 |
(S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidine-2-carboxylic acid 2-carbamoylmethoxy-5-chloro-benzylamide |
816000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| KLKB1 |
(S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-amino)-acetyl]-pyrrolidine-2-carboxylic acid 2,5-dichloro-benzylamide |
399000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| KLKB1 |
(12Z)-19-amino-21-methyl-6-(pyrazol-1-ylmethyl)-9,16-dioxa-1,18,24,28-tetrazatetracyclo[24.2.1.03,8.017,22]nonacosa-3(8),4,6,12,17(22),18,20,26(29),27-nonaen-25-one |
NA |
3000000 |
NA |
NA |
NA |
NA |
TTD |
| KLKB1 |
(S)-1-(3-Phenyl-3-pyridin-4-yl-propionyl)-pyrrolidine-2-carboxylic acid (4-amino-cyclohexylmethyl)-amide; TFA |
1000000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| KLKB1 |
(S)-1-(3-Phenyl-3-pyridin-3-yl-propionyl)-pyrrolidine-2-carboxylic acid (4-amino-cyclohexylmethyl)-amide; TFA |
476000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| KLKB1 |
(S)-1-(3-Phenyl-3-pyridin-2-yl-propionyl)-pyrrolidine-2-carboxylic acid (4-amino-cyclohexylmethyl)-amide; TFA |
767000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| KLKB1 |
(S)-1-(3-Benzo[1,3]dioxol-5-yl-3-pyridin-3-yl-propionyl)-pyrrolidine-2-carboxylic acid (4-amino-cyclohexylmethyl)-amide; TFA |
1000000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| KLKB1 |
methyl (2S,4S)-4-amino-2-[[(2S,4S)-4-amino-2-[3-[(1R,3R)-3-[[(2S,4S)-4-amino-2-[[(2S,4S)-4-amino-5-(1H-indol-3-yl)-3-oxo-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-5-(1H-indol-3-yl)-3-oxopentanoyl]amino]-2-oxocyclohexyl]propanoylamino]-5-(1H-indol-3-yl)-3-oxopentanoyl]amino]-5-(4-hydroxyphenyl)-3-oxopentanoate |
NA |
400000 |
NA |
NA |
NA |
NA |
TTD |
| KLKB1 |
tert-butyl 3-[3-[5-[[(1S)-5-amino-1-cyanopentyl]carbamoyl]-2-(pyridin-4-ylmethoxy)anilino]-3-oxopropyl]indole-1-carboxylate |
NA |
910000 |
NA |
NA |
NA |
NA |
TTD |
| KLKB1 |
6-amino-N-[(3S,7E,9S,12R,16S,19S)-16-[[3-(aminomethyl)phenyl]methyl]-12-[(2S)-butan-2-yl]-9-[(4-hydroxyphenyl)methyl]-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentazabicyclo[17.3.0]docos-7-en-3-yl]hexanamide |
2000000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| KLKB1 |
N-[(1S)-5-amino-1-cyanopentyl]-3-[(2-naphthalen-2-ylacetyl)amino]-4-(pyridin-4-ylmethoxy)benzamide |
NA |
380000 |
NA |
NA |
NA |
NA |
TTD |
| KLKB1 |
N-[(3S,7E,9S,12R,16S,19S)-16-[[3-(aminomethyl)phenyl]methyl]-12-[(2S)-butan-2-yl]-9-[(4-hydroxyphenyl)methyl]-2,6,11,14,18-pentaoxo-1,5,10,13,17-pentazabicyclo[17.3.0]docos-7-en-3-yl]acetamide |
3300000 |
NA |
NA |
NA |
NA |
NA |
TTD |
| KLKB1 |
N-[(1S)-5-amino-1-cyanopentyl]-3-[(2-naphthalen-1-ylacetyl)amino]-4-(pyridin-4-ylmethoxy)benzamide |
NA |
680000 |
NA |
NA |
NA |
NA |
TTD |