| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| MDM2 |
Isoindolinone scaffold, 38 |
NA |
191000 |
NA |
NA |
NA |
NA |
BindingDB |
| MDM2 |
Isoindolinone scaffold, 44 |
NA |
490000 |
NA |
NA |
NA |
NA |
BindingDB |
| MDM2 |
Isoindolinone scaffold, 51 |
NA |
380000 |
NA |
NA |
NA |
NA |
BindingDB |
| MDM2 |
Isoindolinone scaffold, 58 |
NA |
290000 |
NA |
NA |
NA |
NA |
BindingDB |
| MDM2 |
Isoindolinone scaffold, 20 |
NA |
393000 |
NA |
NA |
NA |
NA |
BindingDB |
| MDM2 |
Isoindolinone scaffold, 26 |
NA |
281000 |
NA |
NA |
NA |
NA |
BindingDB |
| MDM2 |
Isoindolinone scaffold, 28 |
NA |
315000 |
NA |
NA |
NA |
NA |
BindingDB |
| MDM2 |
Isoindolinone scaffold, 31 |
NA |
206000 |
NA |
NA |
NA |
NA |
BindingDB |
| MDM2 |
Isoindolinone scaffold, 33 |
NA |
214000 |
NA |
NA |
NA |
NA |
BindingDB |
| MDM2 |
Isoindolinone scaffold, 37 |
NA |
243000 |
NA |
NA |
NA |
NA |
BindingDB |
| MDM2 |
Isoindolinone scaffold, 39 |
NA |
232000 |
NA |
NA |
NA |
NA |
BindingDB |
| MDM2 |
Isoindolinone scaffold, 48 |
NA |
413000 |
NA |
NA |
NA |
NA |
BindingDB |
| MDM2 |
Isoindolinone scaffold, 50 |
NA |
275000 |
NA |
NA |
NA |
NA |
BindingDB |
| MDM2 |
1-[1-[(5-methylol-2-furyl)methyl]-4-piperidyl]-N-phenethyl-isonipecotamide |
NA |
NA |
NA |
3273410 |
NA |
NA |
BindingDB |
| MDM2 |
(4S)-4-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-[[(3R,6S,9S,12S,15S,18S,21S,24R)-3-[[(2S)-6-amino-1-[[(2S)-5-amino-1-[[(2S)-1-[[2-[[2-[[2-[[2-[[(2S)-1-amino-6-[(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carbonyl)amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxohexan-2-yl]carbamoyl]-9,15-bis(4-aminobutyl)-6,12-bis(2-carboxyethyl)-21-(1H-indol-3-ylmethyl)-18-(2-methylpropyl)-5,8,11,14,17,20,23,28,35-nonaoxo-1,26-dithia-4,7,10,13,16,19,22,29,34-nonazacyclohexatriacont-24-yl]amino]-5-oxopentanoic acid |
NA |
NA |
140000 |
NA |
NA |
NA |
BindingDB |
| MDM2 |
(4S)-4-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-[[(3R,6S,9S,12S,15S,18S,21S,24R)-3-[[(2S)-6-amino-1-[[(2S,3S)-1-[[(2S)-1-[[2-[[2-[[2-[[2-[[(2S)-1-amino-6-[(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carbonyl)amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]carbamoyl]-15-(4-aminobutyl)-9-(3-amino-3-oxopropyl)-6,12-bis(2-carboxyethyl)-21-(1H-indol-3-ylmethyl)-18-(2-methylpropyl)-5,8,11,14,17,20,23,28,35-nonaoxo-1,26-dithia-4,7,10,13,16,19,22,29,34-nonazacyclohexatriacont-24-yl]amino]-5-oxopentanoic acid |
NA |
NA |
156000 |
NA |
NA |
NA |
BindingDB |
| MDM2 |
(4S)-4-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-[[(3R,6S,9S,15S,18S,21S,24R)-3-[[(2S)-6-amino-1-[[(2S)-6-amino-1-[[(2S)-1-[[2-[[2-[[2-[[2-[[(2S)-1-amino-6-[(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carbonyl)amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]carbamoyl]-9,15-bis(4-aminobutyl)-6,12-bis(2-carboxyethyl)-21-(1H-indol-3-ylmethyl)-18-(2-methylpropyl)-5,8,11,14,17,20,23,28,35-nonaoxo-1,26-dithia-4,7,10,13,16,19,22,29,34-nonazacyclohexatriacont-24-yl]amino]-5-oxopentanoic acid |
NA |
NA |
178000|571000 |
NA |
NA |
NA |
BindingDB |
| MDM2 |
(4S)-4-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-[[(9R,12S,15S,18S,21S,24S,27S,30R)-9-[[(2S)-6-amino-1-[[(2S)-5-amino-1-[[(2S)-1-[[2-[[2-[[2-[[2-[[(2S)-1-amino-6-[(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carbonyl)amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxohexan-2-yl]carbamoyl]-21-(4-aminobutyl)-24-(2-amino-2-oxoethyl)-18-(2-carboxyethyl)-27-[(1R)-1-hydroxyethyl]-12-(1H-indol-3-ylmethyl)-15-(2-methylpropyl)-11,14,17,20,23,26,29-heptaoxo-7,32-dithia-10,13,16,19,22,25,28-heptazatricyclo[32.2.2.22,5]tetraconta-1(37),2(40),3,5(39),34(38),35-hexaen-30-yl]amino]-5-oxopentanoic acid |
NA |
NA |
270000 |
NA |
NA |
NA |
BindingDB |
| MDM2 |
(4S)-4-[[(2S)-6-amino-2-[[(2S)-4-amino-2-[[(2S,3R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-3-sulfanylpropanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]hexanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-6-amino-1-[[(2S)-5-amino-1-[[(2S)-1-[[2-[[2-[[2-[[2-[[(2S)-1-amino-6-[(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carbonyl)amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid |
NA |
NA |
553000 |
NA |
NA |
NA |
BindingDB |
| MDM2 |
(4S)-4-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-carboxybutanoyl]amino]-3-sulfanylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]amino]-5-[[(2S)-5-amino-1-[[(2S)-1-[[(2R)-1-[[(2S)-6-amino-1-[[(2S,3S)-1-[[(2S)-1-[[2-[[2-[[2-[[2-[[(2S)-1-amino-6-[(3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carbonyl)amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-oxopentanoic acid |
NA |
NA |
116000|445000 |
NA |
NA |
NA |
BindingDB |