| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| HSD11B1 |
(1S,5R)-1-[[tert-butyl(dimethyl)silyl]oxymethyl]-8-methyl-4-propan-2-ylspiro[4.5]deca-3,8-dien-10-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R)-1-(hydroxymethyl)-4-(phenylmethoxymethyl)spiro[4.5]deca-3,9-dien-8-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R)-4-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-1-(hydroxymethyl)spiro[4.5]deca-3,9-dien-8-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R)-1-(ethoxymethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(2S,3R)-6'-oxospiro[1,2-dihydroindene-3,3'-cyclohexene]-2-carboxylic acid |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
4-methoxy-N-[[1-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]triazol-4-yl]methyl]benzenesulfonamide |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
tert-butyl N-[[1-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]triazol-4-yl]methyl]carbamate |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R)-N-[5-(4-chlorophenyl)-1,3-thiazol-2-yl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide |
NA |
122000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,4'S,5R,6S)-4'-(hydroxymethyl)-1'-propan-2-ylspiro[7-oxabicyclo[4.1.0]heptane-5,5'-cyclopentene]-2-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R,8R)-1-[[tert-butyl(dimethyl)silyl]oxymethyl]-8-hydroxy-8-methyl-4-propan-2-ylspiro[4.5]deca-3,9-dien-2-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,2S,4'S,5R,6S)-4'-(hydroxymethyl)-2-methyl-1'-propan-2-ylspiro[7-oxabicyclo[4.1.0]heptane-5,5'-cyclopentene]-2-ol |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R)-1-[(5-hexylsulfanyl-1,3,4-thiadiazol-2-yl)sulfonylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one |
NA |
121000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R)-1-(1,3-benzoxazol-2-ylsulfonylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R)-1-(1,3-benzothiazol-2-ylsulfonylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,4S,5S,8R,9S)-1-(hydroxymethyl)-8-methyl-4-propan-2-ylspiro[4.5]decane-8,9-diol |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R)-1-(1,3-benzoxazol-2-ylsulfanylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R)-1-(1,3-benzothiazol-2-ylsulfanylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R,8R,10R)-1-(hydroxymethyl)-8-methyl-4-propan-2-ylspiro[4.5]dec-3-ene-8,10-diol |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
tert-butyl-[(1S,4R,4'S,6S)-4'-[[tert-butyl(dimethyl)silyl]oxymethyl]-1'-propan-2-ylspiro[7-oxabicyclo[4.1.0]heptane-4,5'-cyclopentene]-1-yl]oxy-dimethylsilane |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
ethyl (1S,4S,5S)-8-oxo-1-propan-2-ylspiro[4.5]dec-9-ene-4-carboxylate |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |