| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| HSD11B1 |
2-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]isoindole-1,3-dione |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R)-1-[(1-phenyltetrazol-5-yl)sulfonylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one |
NA |
245000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R,8R,9S)-1-(hydroxymethyl)-8-methyl-4-propan-2-ylspiro[4.5]dec-3-ene-8,9-diol |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
ethyl (1S,5R)-4-methylidene-8-oxospiro[4.5]dec-9-ene-1-carboxylate |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,3aS,5aR,7R,9aS)-7-methyl-1-propan-2-yl-2,3,3a,4,5a,6,8,9-octahydro-1H-cyclopenta[c][1]benzofuran-7-ol |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,2R,2'S,5S,5'S,6S)-2'-(hydroxymethyl)-2-methyl-5'-propan-2-ylspiro[7-oxabicyclo[4.1.0]heptane-5,1'-cyclopentane]-2-ol |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxylic acid |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(2S,3R)-2-(hydroxymethyl)spiro[1,2-dihydroindene-3,4'-cyclohex-2-ene]-1'-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
ethyl (1S,4S,5R,9S)-9-acetyloxy-8-oxo-1-propan-2-ylspiro[4.5]decane-4-carboxylate |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
ethyl (1S,4S,5S,7S)-7-acetyloxy-8-methylidene-9-oxo-1-propan-2-ylspiro[4.5]decane-4-carboxylate |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R,8S,9S)-1-(hydroxymethyl)-8-methyl-4-propan-2-ylspiro[4.5]dec-3-ene-8,9-diol |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R)-N-[(3,5-difluorophenyl)methyl]-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-diene-1-carboxamide |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R)-8-oxo-4-propan-2-yl-N-(2-thiophen-2-ylethyl)spiro[4.5]deca-3,9-diene-1-carboxamide |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
1,1-dioxo-2-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]-1,2-benzothiazol-3-one |
NA |
341000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
4-amino-N-[[1-[[(1S,5R)-8-oxo-4-propan-2-ylspiro[4.5]deca-3,9-dien-1-yl]methyl]triazol-4-yl]methyl]-N-pyrimidin-2-ylbenzenesulfonamide |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R)-1-(naphthalen-2-ylsulfanylmethyl)-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R)-1-[(1-phenyltetrazol-5-yl)sulfanylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
(1S,5R)-1-[(5-hexylsulfanyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-4-propan-2-ylspiro[4.5]deca-3,9-dien-8-one |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| HSD11B1 |
[(1S,5R)-8-methyl-4-propan-2-ylspiro[4.5]deca-3,8-dien-1-yl]methanol |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |