| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| CTSD |
US9611261, Example 297 |
NA |
834640 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
2-N'-(3-ethoxypyridin-2-yl)-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2,2'-diamine |
NA |
400000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
US9611261, Example 433 |
NA |
612810 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
2-N'-(3-ethoxypyridin-2-yl)-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-thiazine-4,9'-xanthene]-2,2'-diamine |
NA |
262500 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-isocyanopyridine-2-carboxamide |
NA |
2200000|3120000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-4,5-difluorophenyl]-5-isocyanopyridine-2-carboxamide |
NA |
901000|1790000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
5'-fluoro-7'-methoxy-2-N'-(3-phenylmethoxypyridin-2-yl)spiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2,2'-diamine |
NA |
400000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[2-amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyrazine-2-carboxamide |
NA |
400000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-(2-amino-1'-fluoro-3'-pyridin-3-ylspiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl)-5-fluoropyrazine-2-carboxamide |
NA |
357900 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-(2-amino-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl)-5-cyanopyridine-2-carboxamide |
NA |
147000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-(2-amino-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl)-5-methoxypyrazine-2-carboxamide |
NA |
400000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-(2-amino-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl)-4-chloro-2-fluorobenzamide |
NA |
400000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-(2-amino-5'-fluoro-7'-methoxyspiro[5,6-dihydro-1,3-oxazine-4,9'-xanthene]-2'-yl)-2-fluoro-4-methoxybenzamide |
NA |
331100 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[2-amino-3'-(3,6-dihydro-2H-pyran-5-yl)-1'-fluorospiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-2-methyl-1,3-thiazole-4-carboxamide |
NA |
411100 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[2-amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-2-methyl-1,3-thiazole-4-carboxamide |
NA |
361600 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[2-amino-1'-fluoro-3'-(5-fluoropyridin-3-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-fluoropyridine-2-carboxamide |
NA |
400000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[2-amino-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-b]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide |
NA |
400800 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[2-amino-1'-fluoro-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide |
NA |
400000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[2-amino-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-methoxypyrazine-2-carboxamide |
NA |
400000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[2-amino-3'-(2-fluoropyridin-4-yl)spiro[5,6-dihydro-1,3-oxazine-4,5'-chromeno[2,3-c]pyridine]-7'-yl]-5-chloropyridine-2-carboxamide |
NA |
400000 |
NA |
NA |
NA |
NA |
BindingDB |