| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| CTSD |
N-[3-[(7R)-9-amino-2-methoxy-7-methyl-5,5-dioxo-5lambda6-thia-8-azaspiro[3.5]non-8-en-7-yl]-4-fluorophenyl]-5-chloro-3-methylpyridine-2-carboxamide |
NA |
466000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(7R)-2,2-difluoro-7-[2-fluoro-5-[(2-methoxypyrido[3,4-b]pyrazin-5-yl)amino]phenyl]-7-methyl-5,5-dioxo-5lambda6-thia-8-azaspiro[3.5]non-8-en-9-amine |
NA |
330000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(7R)-9-amino-7-methyl-5,5-dioxo-5lambda6-thia-8-azaspiro[3.5]non-8-en-7-yl]-4-fluorophenyl]-5-cyano-3-methylpyridine-2-carboxamide |
NA |
134000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(3R)-5-amino-3,6,6-trimethyl-1,1-dioxo-2H-1,4-thiazin-3-yl]-4-fluorophenyl]-5-but-2-ynoxypyridine-2-carboxamide |
NA |
475000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
3-[2-fluoro-5-[(3-methoxy-1,7-naphthyridin-8-yl)amino]pyridin-3-yl]-3,6,6-trimethyl-1,1-dioxo-2H-1,4-thiazin-5-amine |
NA |
101000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(1R,5S,6R)-5-[2,6-difluoro-3-[(2-methoxypyrido[3,4-b]pyrazin-5-yl)amino]phenyl]-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine |
NA |
2745500 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(1R,5S,6R)-5-(5-((cyclobutylmethyl)amino)-2-fluorophenyl)-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine |
NA |
121000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
US9611261, Example 439 |
NA |
489920 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(1R,5S,6R)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-(3-cyclopropylprop-2-ynoxy)pyrazine-2-carboxamide |
NA |
359770 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-(3-((1R,5S,6R)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl)-4-fluorophenyl)-5-chloro-3-methoxypicolinamide |
NA |
907850 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(1R,5S,6R)-5-(5-(((5-chloropyridin-2-yl)methyl)amino)-2-fluorophenyl)-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine |
NA |
177000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
methyl 4-[[3-[(1S,5R,6S)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]carbamoyl]benzoate |
NA |
343180 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
US9605007, Example 4 |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| CTSD |
N-[2-[(4aR,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-5-(difluoromethoxy)pyrazine-2-carboxamide |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| CTSD |
US9605007, Example 5 |
NA |
197600 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| CTSD |
N-[2-[(4aR,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-5-(trifluoromethoxy)pyridine-2-carboxamide |
NA |
163600 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| CTSD |
N-[2-[(4aR,6S,8aR)-2-amino-6-methyl-4a,5,6,8-tetrahydro-4H-pyrano[3,4-d][1,3]thiazin-8a-yl]-1,3-thiazol-4-yl]-5-(trifluoromethyl)pyridine-2-carboxamide |
NA |
300000 |
NA |
NA |
NA |
NA |
TTD |
| CTSD |
N-[3-[(1S,6S)-3-amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-(4-hydroxy-4-methylpent-2-ynoxy)-3-methylpyridine-2-carboxamide |
NA |
462460 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(1R,5S,6R)-3-amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-5-fluoro-4-methylsulfanylphenyl]-5-chloropyridine-2-carboxamide |
NA |
654540 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[6-[(1R,5S,6R)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-5-fluoropyridin-2-yl]-5-isocyanopyridine-2-carboxamide |
NA |
139000|1511900 |
NA |
NA |
NA |
NA |
BindingDB |