| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| CTSD |
N-[3-[(1S,5R,6S)-3-amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-3-methyl-5-(trifluoromethyl)pyridine-2-carboxamide |
NA |
1630100 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(1S,5R,6S)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-6-chloro-3-methylpyrazine-2-carboxamide |
NA |
459520 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(1S,5R,6S)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-chloro-3-methylpyrazine-2-carboxamide |
NA |
577310 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(1S,5R,6S)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-6-chloro-3-methylimidazo[1,2-a]pyridine-2-carboxamide |
NA |
1780300 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[5-[(1S,5R,6S)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-6-fluoropyridin-3-yl]-5-cyanopyridine-2-carboxamide |
NA |
347610 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[5-[(1S,5R,6S)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-6-fluoropyridin-3-yl]-5-chloropyridine-2-carboxamide |
NA |
274500 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(1S,5R,6S)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-4-chloro-1-(difluoromethyl)pyrazole-3-carboxamide |
NA |
1482500 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(1R,5S,6R)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4,5-difluorophenyl]-5-methoxypyridine-2-carboxamide |
NA |
206000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(1S,5R,6S)-3-amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-chloro-5-fluorophenyl]-5-cyanopyridine-2-carboxamide |
NA |
490740 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(1R,5S,6R)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-2-(difluoromethyl)-1,3-oxazole-4-carboxamide |
NA |
238370 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(1R,5S,6R)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-2-[(1S)-1-fluoroethyl]-1,3-oxazole-4-carboxamide |
NA |
1344400 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(1R,6R)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-chlorophenyl]-5-(difluoromethoxy)-3-methylpyridine-2-carboxamide |
NA |
958310 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(1S,5R,6S)-3-amino-5-(trifluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]phenyl]-5-chloropyridine-2-carboxamide |
NA |
489480 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(1S,5R,6S)-3-amino-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-3-chloro-5-cyanopyridine-2-carboxamide |
NA |
2256300 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(2S)-N-[3-[(1R,5S,6R)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-2-(4-chlorophenyl)propanamide |
NA |
270500 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(1R,5S,6R)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-[(1R)-1-cyanoethoxy]pyridine-2-carboxamide |
NA |
668250 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
US9611261, Example 276 |
NA |
918190 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(1R,5S,6R)-5-[5-[[3-(5-chloropyridin-2-yl)oxetan-3-yl]amino]-2-fluorophenyl]-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine |
NA |
163000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[5-[(1S,5R,6S)-3-amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-6-fluoropyridin-3-yl]-5-chloropyridine-2-carboxamide |
NA |
815580 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[5-[(1R,5S,6R)-3-amino-5-methyl-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-6-fluoropyridin-3-yl]-5-chloropyridine-2-carboxamide |
NA |
401920 |
NA |
NA |
NA |
NA |
BindingDB |