| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| CTSD |
US9611261, Example 341 |
NA |
2885600 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(1R,5S,6R)-5-[5-[(7-chloropyrido[3,2-d]pyrimidin-4-yl)amino]-2-fluorophenyl]-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine |
NA |
105750 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(1R,5S,6R)-5-[2-fluoro-5-[(5-fluoro-3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine |
NA |
596190 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(1R,5S,6R)-5-(difluoromethyl)-5-[2-fluoro-5-[(3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine |
NA |
738320 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(1R,5S,6R)-5-[5-[(7-chloropyrido[3,2-d]pyrimidin-4-yl)amino]-2-fluorophenyl]-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine |
NA |
141050 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(1S,5R,6S)-5-[2,6-difluoro-3-[(2-methoxypyrido[3,4-b]pyrazin-5-yl)amino]phenyl]-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine |
NA |
292000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
8-[3-[(1R,5S,6R)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-chloroanilino]-5-fluoro-1,7-naphthyridine-3-carbonitrile |
NA |
192210 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
8-[3-[(1R,5S,6R)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluoroanilino]-5-fluoro-1,7-naphthyridine-3-carbonitrile |
NA |
192210 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(1R,5S,6R)-5-[2-chloro-5-[(3-chloro-1,7-naphthyridin-8-yl)amino]phenyl]-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine |
NA |
251180 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
US9611261, Example 360 |
NA |
843040 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(1R,5S,6R)-5-(difluoromethyl)-5-[2-fluoro-5-[(5-fluoro-3-methoxy-1,7-naphthyridin-8-yl)amino]phenyl]-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine |
NA |
169000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(1R,5S,6R)-5-[5-[(3-chloro-1,7-naphthyridin-8-yl)amino]-2-fluorophenyl]-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine |
NA |
399580 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(1R,5S,6R)-5-(difluoromethyl)-5-[2-fluoro-5-[(2-methoxypyrido[3,4-b]pyrazin-5-yl)amino]phenyl]-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine |
NA |
500520 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(1R,5S,6R)-5-(difluoromethyl)-5-[2-fluoro-5-[(7-methoxypyrido[3,2-d]pyrimidin-4-yl)amino]phenyl]-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine |
NA |
596240 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(1R,5S,6R)-5-(difluoromethyl)-5-[2-fluoro-5-[[(1R,2R)-2-phenylcyclopropyl]methylamino]phenyl]-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine |
NA |
102350 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(1R,5S,6R)-5-[5-[[4-chloro-1-(difluoromethyl)pyrazol-3-yl]methylamino]-2-fluorophenyl]-5-(fluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine |
NA |
234000 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
8-[3-[(1R,5S,6R)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluoroanilino]-1,7-naphthyridine-3-carbonitrile |
NA |
657710 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
(1R,5S,6R)-5-[5-[[4-chloro-1-(difluoromethyl)pyrazol-3-yl]methylamino]-2-fluorophenyl]-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-3-amine |
NA |
115500 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
N-[3-[(1R,5S,6R)-3-amino-5-(difluoromethyl)-2-oxa-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-5-cyano-3-(difluoromethyl)pyridine-2-carboxamide |
NA |
476950 |
NA |
NA |
NA |
NA |
BindingDB |
| CTSD |
US9611261, Example 423 |
NA |
591980 |
NA |
NA |
NA |
NA |
BindingDB |