| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| EPAS1 |
(4S)-5,5-difluoro-3-methylsulfonyl-1-propoxy-4,6-dihydrocyclopenta[c]thiophen-4-ol |
NA |
NA|545000|1390000 |
320000|NA |
NA |
NA |
NA |
BindingDB |
| EPAS1 |
(4S)-1-[(3,3-difluorocyclobutyl)methoxy]-5,5-difluoro-3-methylsulfonyl-4,6-dihydrocyclopenta[c]thiophen-4-ol |
NA |
222000|252000 |
NA |
NA |
NA |
NA |
BindingDB |
| EPAS1 |
(4S)-5,5-difluoro-3-methylsulfonyl-1-propan-2-yloxy-4,6-dihydrocyclopenta[c]thiophen-4-ol |
NA |
NA|4720000|12200000 |
1800000|NA |
NA |
NA |
NA |
BindingDB |
| EPAS1 |
(4S)-5,5-difluoro-3-methylsulfonyl-1-(4,4,4-trifluorobutoxy)-4,6-dihydrocyclopenta[c]thiophen-4-ol |
NA |
NA|456000|558000 |
230000|NA |
NA |
NA |
NA |
BindingDB |
| EPAS1 |
(4S)-1-(2,2-difluoropropoxy)-5,5-difluoro-3-methylsulfonyl-4,6-dihydrocyclopenta[c]thiophen-4-ol |
NA |
243000|280000 |
NA |
NA |
NA |
NA |
BindingDB |
| EPAS1 |
(4S)-1-(cyclopropylmethoxy)-5,5-difluoro-3-methylsulfonyl-4,6-dihydrocyclopenta[c]thiophen-4-ol |
NA |
NA|1110000|1630000 |
300000|NA |
NA |
NA |
NA |
BindingDB |
| EPAS1 |
(4S)-1-(1-cyclobutylethoxy)-5,5-difluoro-3-methylsulfonyl-4,6-dihydrocyclopenta[c]thiophen-4-ol |
NA |
NA|598000|821000 |
320000|NA |
NA |
NA |
NA |
BindingDB |
| EPAS1 |
(4S)-1-(cyclobutylmethoxy)-5,5-difluoro-3-methylsulfonyl-4,6-dihydrocyclopenta[c]thiophen-4-ol |
NA |
181000|367000 |
NA |
NA |
NA |
NA |
BindingDB |
| EPAS1 |
(4S)-1-(3,3-difluorobutoxy)-5,5-difluoro-3-methylsulfonyl-4,6-dihydrocyclopenta[c]thiophen-4-ol |
NA |
NA|398000|634000 |
180000|NA |
NA |
NA |
NA |
BindingDB |
| EPAS1 |
(4S)-5,5-difluoro-1-(2-methylbutoxy)-3-methylsulfonyl-4,6-dihydrocyclopenta[c]thiophen-4-ol |
NA |
150000|199000 |
NA |
NA |
NA |
NA |
BindingDB |
| EPAS1 |
(4S)-5,5-difluoro-3-methylsulfonyl-1-(2,2,2-trifluoroethoxy)-4,6-dihydrocyclopenta[c]thiophen-4-ol |
NA |
353000|616000 |
NA |
NA |
NA |
NA |
BindingDB |
| EPAS1 |
(4S)-5,5-difluoro-3-methylsulfonyl-1-[(2R)-3,3,3-trifluoro-2-methylpropoxy]-4,6-dihydrocyclopenta[c]thiophen-4-ol |
NA |
130000|271000 |
NA |
NA |
NA |
NA |
BindingDB |
| EPAS1 |
Hif-2|A-IN-9 |
NA |
164000|305000 |
NA |
NA |
NA |
NA |
BindingDB |
| EPAS1 |
(1R,4E,6E,10E,14S)-7-(2-methoxypropan-2-yl)-4,10,14-trimethyl-15-oxabicyclo[12.1.0]pentadeca-4,6,10-triene |
NA |
NA |
NA |
148900 |
NA |
NA |
BindingDB|TTD |
| EPAS1 |
(1R,2E,6R,8S,11E)-3,8,12,16-tetramethyl-7,18-dioxatricyclo[13.3.0.06,8]octadeca-2,11,15-triene |
NA |
NA |
NA |
183300 |
NA |
NA |
BindingDB|TTD |
| EPAS1 |
(1R,3S,14S)-6,10,14-trimethyl-3-(prop-1-en-2-yl)-15-oxabicyclo[12.1.0]pentadeca-6,10-dien-5-one |
NA |
NA |
NA |
107500 |
NA |
NA |
BindingDB|TTD |
| EPHA2 |
Glycolithocholic acid |
NA |
138000 |
NA |
NA |
NA |
NA |
BindingDB |
| EPHA2 |
(2S)-2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]butanedioic acid |
NA |
316227.77 |
NA |
NA |
NA |
NA |
TTD |
| EPHA2 |
(2S)-3-hydroxy-2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]propanoic acid |
NA |
101000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| EPHA2 |
(2S)-4-amino-2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]-4-oxobutanoic acid |
NA |
316227.77 |
NA |
NA |
NA |
NA |
TTD |