| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| BACE1 |
6-Bromoquinolin-2-amine |
NA |
NA|338000 |
266000|NA |
NA |
NA |
NA |
BindingDB|TTD |
| BACE1 |
6-(Trifluoromethyl)quinolin-2-amine |
NA |
NA |
3900000 |
NA |
NA |
NA |
BindingDB |
| BACE1 |
2-Aminoquinoline |
NA |
NA|800000|2000000 |
900000|NA |
NA |
NA |
NA |
BindingDB|TTD |
| BACE1 |
6-Fluoroquinolin-2-amine |
NA |
NA |
1000000|1280000 |
NA |
NA |
NA |
BindingDB |
| BACE1 |
3-(3-Chlorophenyl)imidazo[1,2-a]pyrimidine |
NA |
862000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| BACE1 |
2,3,4,4-Tetramethyl-5-methylidenecyclopent-2-en-1-one |
NA|415800|416000 |
NA |
NA |
217000|NA |
NA |
NA |
BindingDB|TTD |
| BACE1 |
6-(3-(pyridin-3-yl)phenethyl)-2-amino-3-methylpyrimidin-4(3H)-one |
NA |
190000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| BACE1 |
|
NA |
130000 |
NA |
NA |
NA |
NA |
BindingDB |
| BACE1 |
6-(3-(1H-pyrrol-2-yl)phenethyl)-2-amino-3-methylpyrimidin-4(3H)-one |
NA |
120000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| BACE1 |
(4S)-4-amino-5-[[(2S,3S)-1-[[(2S)-1-[[(2S,3S)-4-[[(1S)-1-carboxybutyl]amino]-3-hydroxy-1-thiophen-2-ylbutan-2-yl]amino]-1-oxo-3-thiophen-2-ylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid |
NA |
2000000 |
NA |
NA |
NA |
NA |
TTD |
| BACE1 |
(4S)-4-amino-5-[[(2S,3S)-1-[[(2S)-1-[[(2S,3S)-1-[[(1S)-1-carboxybutyl]amino]-2-hydroxy-5-methylhexan-3-yl]amino]-1-oxo-3-thiophen-2-ylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| BACE1 |
(4S)-4-amino-5-[[(2S,3S)-1-[[(2S)-1-[[(3S,4S)-2-[[(1S)-1-carboxybutyl]amino]-3-hydroxy-6-methylheptan-4-yl]amino]-1-oxo-3-thiophen-2-ylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| BACE1 |
(4S)-4-amino-5-[[(2S,3S)-1-[[(2S)-1-[[(2S,3S)-1-[[(1S)-1-carboxybutyl]-methylamino]-2-hydroxy-5-methylhexan-3-yl]amino]-1-oxo-3-thiophen-2-ylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| BACE1 |
H-Glu-Ile-2Thi-bAla(2S-OH,3S-thien-2-ylmethyl)-Nva-OH |
NA |
870000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| BACE1 |
H-Glu-Ile-2Thi-bAla(2S-OH,3S-iBu)-Nva-OH |
NA |
1000000 |
NA |
NA |
NA |
NA |
TTD |
| BACE1 |
H-Glu-Ile-2Thi-bAla(2S-OH,3S-CH2cHex)-Nva-OH |
NA |
480000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| BACE1 |
H-Glu-Ile-2Thi-bAla(2S-OH,3S-Bn)-Nva-OH |
NA |
870000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| BACE1 |
(4S)-4-amino-5-[[(2S,3S)-1-[[(2S)-1-[[(2R,3S)-1-[[(1S)-1-carboxybutyl]-methylamino]-2-hydroxy-5-methylhexan-3-yl]amino]-1-oxo-3-thiophen-2-ylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acid |
NA |
680000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| BACE1 |
6-(2-Phenylethyl)pyridin-2-amine |
NA |
2000000 |
NA |
NA |
NA |
NA |
TTD |
| BACE1 |
7-(3-fluoranylpyridin-4-yl)-1~{H}-imidazo[4,5-b]pyridin-2-amine |
NA |
200000 |
NA |
NA |
NA |
NA |
TTD |