| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| ITPKA |
Purine, 8 |
NA |
102000 |
NA |
NA |
NA |
NA |
BindingDB |
| ITPKA |
6-N-benzyl-2-N-[(4-fluorophenyl)methyl]-7H-purine-2,6-diamine |
NA |
220000 |
NA |
NA |
NA |
NA |
BindingDB |
| ITPKA |
2-N-[(4-chlorophenyl)methyl]-6-N-phenyl-7H-purine-2,6-diamine |
NA |
150000 |
NA |
NA |
NA |
NA |
BindingDB |
| ITPKA |
Purine, 15 |
NA |
117000 |
NA |
NA |
NA |
NA |
BindingDB |
| ITPR1 |
(2,5-Dihydroxy-3,4-diphosphonooxycyclohexyl) dihydrogen phosphate |
292000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| JAK1 |
(1R,2S)-4,4-difluoro-2-[3-[3-methyl-4-(pyrrolidine-1-carbonyl)anilino]-4-oxo-3,3a,5,6,7,7a-hexahydro-2H-pyrazolo[4,3-c]pyridin-1-yl]cyclopentane-1-carbonitrile |
NA |
114000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK1 |
|
380000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
1H-Pyrrole-3-carboxamide, 5-((5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-N-((2S)-2-hydroxy-3-(4-morpholinyl)propyl)-2,4-dimethyl- |
1600000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
Benzamide, N-[6-[(6,7-dimethoxy-4-quinolinyl)oxy]-1-methyl-1H-indazol-3-yl]-3-(trifluoromethyl)- |
NA |
25000000 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| JAK2 |
Ast-487 |
910000 |
NA |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
6-phenyl-1H-indazol-3-amine |
NA |
145300 |
NA |
NA |
NA |
NA |
BindingDB|TTD |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(4H-1,2,4-triazole-3-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
104000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile |
NA |
943000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoropiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
409000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((6-(2-hydroxypropan-2-yl)pyridin-3-yl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 3 |
NA |
724000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((4-(4-(Oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-(1-oxa-6-azaspiro[3.4]octan-6-yl)benzonitrile |
NA |
258000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((4-(1,1-dioxidothiomorpholino)phenyl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile |
NA |
360000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(R)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-(pyrrolidin-3-yloxy)benzonitrile |
NA |
961000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(1H-pyrazole-5-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
219000 |
NA |
NA |
NA |
NA |
BindingDB |