| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| JAK2 |
(R)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-(1-(tetrahydro-2H-pyran-4-yl)ethoxy)benzonitrile |
NA |
450000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 338 |
NA |
131000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 350 |
NA |
231000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((4-(3-hydroxy-3-methylazetidin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
496000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-Methoxy-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
328000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 267 |
NA |
404000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(R)-2-(3-hydroxypyrrolidin-1-yl)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
192000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R)-3-fluoro-1-((S)-5-oxopyrrolidine-2-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
375000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-1-(2-cyanoacetyl)-3-fluoropiperidin-4-yl)oxy)-3-fluoro-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
941000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(R)-2-((1-formylpyrrolidin-3-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
377000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((3,3-difluoro-1-(1H-imidazole-2-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
248000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(3-Hydroxyazetidin-1-yl)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
166000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((3-methoxy-4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile |
NA |
127000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((4,4-difluoro-1-((S)-2-hydroxypropanoyl)pyrrolidin-3-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
265000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(S)-2-((1-acetyl-3,3-difluoropiperidin-4-yl)oxy)-5-(4-((4-(piperidin-4-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
308000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 159 |
NA |
207000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 288 |
NA |
316000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(3-methyloxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
636000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 222 |
NA |
182000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 387 |
NA |
638000 |
NA |
NA |
NA |
NA |
BindingDB |