| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| JAK2 |
5-(4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-[4-[4-[4-(Oxetan-3-yl)piperazin-1-yl]anilino]-1,3,5-triazin-2-yl]-2-(1-oxidothian-1-ium-4-yl)oxybenzonitrile |
NA |
407000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 14 |
NA |
856000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-4-yl)oxy)-5-(4-((6-(2-hydroxypropan-2-yl)pyridin-3-yl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 117 |
NA |
109000|342000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(R)-4-(4-((4-(3-cyano-4-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)phenyl)-1,3,5-triazin-2-yl)amino)phenyl)morpholine-2-carboxamide |
NA |
564000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((1-(2-Hydroxyacetyl)-2,6-dimethylpiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
463000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 264 |
NA |
296000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 228 |
NA |
206000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((4-Methyl-1,2,3-thiadiazol-5-yl)methoxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
605000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((4-(4-(2-hydroxyacetyl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile |
NA |
347000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((3-fluoro-4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile |
NA |
988000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 317 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((3,3-Difluoro-1-(2-hydroxyacetyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
122000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 120 |
NA |
674000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((4-((R)-3-(hydroxymethyl)morpholino)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
568000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(S)-2-((1-acetyl-3,3-difluoropiperidin-4-yl)oxy)-5-(4-((4-(1-methylpiperidin-4-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
174000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 378 |
NA |
173000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-4-yl)oxy)-5-(4-((3-fluoro-4-(4-(tetrahydro-2H-pyran-4-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
268000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 150 |
NA |
270000 |
NA |
NA |
NA |
NA |
BindingDB |