| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| JAK2 |
(R)-4-((4-(3-cyano-4-(pyrrolidin-3-yloxy)phenyl)-1,3,5-triazin-2-yl)amino)-N-isopropylbenzamide |
NA |
805000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 542 |
NA |
363000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
3-Methoxy-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
212000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((3,3-difluoro-1-((R)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
188000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(3-Methoxyazetidin-1-yl)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
219000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((2R,4R)-1-((R)-2-hydroxypropanoyl)-2-methylpiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 503 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((1-(tert-butyl)-1H-pyrazol-4-yl)amino)-1,3,5-triazin-2-yl)-2-(((3R,4S)-1-(2-cyanoacetyl)-3-fluoropiperidin-4-yl)oxy)benzonitrile |
NA |
108000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 149 |
NA |
330000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
4-(4-((4-(3-cyano-4-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)phenyl)-1,3,5-triazin-2-yl)amino)phenyl)morpholine-2-carboxamide |
NA |
609000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((4-(4-((S)-2-hydroxypropyl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
969000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
rac-2-(((1S,2R)-2-fluorocyclohexyl)oxy)-5-(4-((4-(piperidin-4-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
415000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(R)-2-((1-(2-hydroxyacetyl)pyrrolidin-3-yl)oxy)-5-(4-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
459000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((3,3-difluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
168000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 265 |
NA |
426000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 235 |
NA |
317000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(2-Methyl-2,7-diazaspiro[3.5]nonan-7-yl)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
307000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 512 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 460 |
NA |
131000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 571 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |