| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| JAK2 |
5-(4-((3-morpholinophenyl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile |
NA |
938000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 340 |
NA |
122000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 8 |
NA |
278000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 567 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-1-(5-chloro-1H-pyrazole-4-carbonyl)-3-fluoropiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
167000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-4-yl)oxy)-5-(4-((2-(2-hydroxypropan-2-yl)pyridin-4-yl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
960000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4R)-4-fluoro-1-(2-hydroxyacetyl)pyrrolidin-3-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-4-fluoro-1-(2-hydroxyacetyl)pyrrolidin-3-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
638000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((4-(4-(Oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-(8-oxa-2-azaspiro[4.5]decan-2-yl)benzonitrile |
NA |
137000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,5R)-1-(2-hydroxyacetyl)-5-methylpyrrolidin-3-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
440000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((2R,4S)-1-((R)-2-hydroxypropanoyl)-2-methylpiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((3-Methyloxetan-3-yl)methoxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
178000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((2S,4S)-1-((S)-2-hydroxypropanoyl)-2-methylpiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
432000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-1-(4-chloro-1H-pyrazole-5-carbonyl)-3-fluoropiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
192000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(R)-2-((1-(2-hydroxyacetyl)pyrrolidin-3-yl)oxy)-5-(4-((3-morpholinophenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
290000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 114 |
NA |
175000|200000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 408 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 370 |
NA |
875000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 254 |
NA |
151000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 229 |
NA |
189000 |
NA |
NA |
NA |
NA |
BindingDB |