| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| JAK2 |
2-((3,3-Difluoropiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
242000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
3-(4-((4-(4-(Oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
657000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 238 |
NA |
445000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 46 |
NA |
670000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((4-(1-(oxetan-3-yl)piperidin-4-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(R)-2-((1-(2-hydroxyacetyl)pyrrolidin-3-yl)oxy)-5-(4-((4-morpholinophenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
260000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 225 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-1-((S)-2,3-dihydroxypropanoyl)-3-fluoropiperidin-4-yl)oxy)-5-(4-((1-isopropyl-1H-pyrazol-4-yl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
354000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 611 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 273 |
NA |
133000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 257 |
NA |
270000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxy-3-methylbutanoyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
930000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((4-(piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
358000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((S)-2-oxooxazolidine-4-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
233000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(Cyclopropylmethoxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
455000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(3-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
408000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(R)-2-(5-hydroxy-2-oxopiperidin-1-yl)-5-(4-((3-methoxy-4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
174000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-1-(2-cyanoacetyl)-3-fluoropiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
146000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 236 |
NA |
723000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 479 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |