| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| JAK2 |
(S)-2-((1-(2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((3-methoxy-4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
185000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(R)-2-((1-(2-hydroxypropanoyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
626000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 374 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 66 |
NA |
345000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 361 |
NA |
317000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((1-(tert-butyl)-1H-pyrazol-4-yl)amino)-1,3,5-triazin-2-yl)-2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-4-yl)oxy)benzonitrile |
NA |
190000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(4-methyl-1H-pyrazole-5-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
368000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 375 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 471 |
NA |
702000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((4-(7-oxa-2-azaspiro[3.5]nonan-2-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)benzonitrile |
NA |
375000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((2S,4S)-1-(2-hydroxyacetyl)-2-methylpiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
230000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 376 |
NA |
127000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(R)-2-((1-(2-hydroxyacetyl)pyrrolidin-3-yl)oxy)-5-(4-((3-methoxy-4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
128000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 509 |
NA |
699000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R)-3-fluoro-1-((R)-5-oxopyrrolidine-2-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
292000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 247 |
NA |
333000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-1-(2-hydroxyacetyl)-4-methylpyrrolidin-3-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 517 |
NA |
828000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 554 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((tetrahydro-2H-pyran-4-yl)oxy)-5-(4-((4-(2,2,2-trifluoroacetyl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
415000 |
NA |
NA |
NA |
NA |
BindingDB |