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Drugs And Genes
Negative Drug Target Genes
GENE_SYMBOL DRUG_NAME Ki (nM) IC50 (nM) Kd (nM) EC50 (nM) Potency (nM) AC50 (nM) Datasource
JAK2 US10040781, Example 364 NA 634000 NA NA NA NA BindingDB
JAK2 US10040781, Example 365 NA 474000 NA NA NA NA BindingDB
JAK2 US10040781, Example 189 NA 289000 NA NA NA NA BindingDB
JAK2 US10040781, Example 424 NA 1000000 NA NA NA NA BindingDB
JAK2 2-(((1S,2R)-2-aminocyclohexyl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile NA 474000 NA NA NA NA BindingDB
JAK2 (S)-2-((3,3-difluoro-1-(1H-pyrazole-5-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile NA 155000 NA NA NA NA BindingDB
JAK2 US10040781, Example 196 NA 118000 NA NA NA NA BindingDB
JAK2 5-(4-((4-Morpholinophenyl)amino)-1,3,5-triazin-2-yl)-2-(pyrrolidin-1-yl)benzonitrile NA 261000 NA NA NA NA BindingDB
JAK2 US10040781, Example 475 NA 1000000 NA NA NA NA BindingDB
JAK2 2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-4-yl)oxy)-5-(4-((4-(1-(oxetan-3-yl)piperidin-4-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile NA 292000 NA NA NA NA BindingDB
JAK2 US10040781, Example 248 NA 187000 NA NA NA NA BindingDB
JAK2 2-(((3R,4S)-3-fluoro-1-((R)-3-fluoropyrrolidine-1-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile NA 681000 NA NA NA NA BindingDB
JAK2 US10040781, Example 343 NA 258000 NA NA NA NA BindingDB
JAK2 US10040781, Example 473 NA 771000 NA NA NA NA BindingDB
JAK2 5-(4-((4-(4-(Oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-(2-oxa-6-azaspiro[3.4]octan-6-yl)benzonitrile NA 236000 NA NA NA NA BindingDB
JAK2 US10040781, Example 234 NA 669000 NA NA NA NA BindingDB
JAK2 US10040781, Example 328 NA 1000000 NA NA NA NA BindingDB
JAK2 (S)-2-((3,3-difluoro-1-formylpiperidin-4-yl)oxy)-5-(4-((3-methyl-4-(1-methylpiperidin-4-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile NA 1000000 NA NA NA NA BindingDB
JAK2 US10040781, Example 127 NA 394000 NA NA NA NA BindingDB
JAK2 2-(((3R,4S)-3-fluoro-1-(2-hydroxyacetyl)piperidin-4-yl)oxy)-5-(4-((4-methylthiazol-5-yl)amino)-1,3,5-triazin-2-yl)benzonitrile NA 1000000 NA NA NA NA BindingDB