| GENE_SYMBOL |
DRUG_NAME |
Ki (nM) |
IC50 (nM) |
Kd (nM) |
EC50 (nM) |
Potency (nM) |
AC50 (nM) |
Datasource |
| JAK2 |
US10040781, Example 37 |
NA |
326000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 5 |
NA |
269000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((1-(1H-pyrrole-2-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(R)-2-((1-(methylsulfonyl)pyrrolidin-3-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
173000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-((1-(2-Hydroxyacetyl)azepan-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
241000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((2S,4R)-4-fluoro-5-oxopyrrolidine-2-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((4R,5S)-1-(2-cyanoacetyl)-5-fluoro-3,3-dimethylpiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
443000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 556 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-1-(2,3-dihydroxypropanoyl)-3-fluoropiperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
162000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
5-(4-((3,3-dimethyl-2-oxoindolin-5-yl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)benzonitrile |
NA |
541000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-((S)-2-hydroxypropanoyl)piperidin-4-yl)oxy)-3-methyl-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
N-(2-(4-(2-cyano-4-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)phenoxy)piperidin-1-yl)-2-oxoethyl)acetamide |
NA |
491000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 476 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(R)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)-2-((tetrahydrofuran-3-yl)oxy)benzonitrile |
NA |
546000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
2-(((3R,4S)-3-fluoro-1-(1H-imidazole-5-carbonyl)piperidin-4-yl)oxy)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
156000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 360 |
NA |
185000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 401 |
NA |
1000000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 308 |
NA |
475000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
(R)-2-(3-fluoropyrrolidin-1-yl)-5-(4-((4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)amino)-1,3,5-triazin-2-yl)benzonitrile |
NA |
109000 |
NA |
NA |
NA |
NA |
BindingDB |
| JAK2 |
US10040781, Example 440 |
NA |
110000 |
NA |
NA |
NA |
NA |
BindingDB |